5WOR

Corkscrew assembly of SOD1 residues 28-38 with familial mutation G37R

5WOR の概要

• エントリーDOI: 10.2210/pdb5wor/pdb
• 分子名称: Superoxide dismutase [Cu-Zn], MALONATE ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: amyloid-related oligomer, protein fibril
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 13574.88

構造登録者

Sangwan, S.,Sawaya, M.R.,Eisenberg, D.S. (登録日: 2017-08-02, 公開日: 2018-05-30, 最終更新日: 2023-10-04)

主引用文献

Sangwan, S.,Sawaya, M.R.,Murray, K.A.,Hughes, M.P.,Eisenberg, D.S.
Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.
Protein Sci., 27:1231-1242, 2018

PubMed Abstract: The aggregation cascade of disease-related amyloidogenic proteins, terminating in insoluble amyloid fibrils, involves intermediate oligomeric states. The structural and biochemical details of these oligomers have been largely unknown. Here we report crystal structures of variants of the cytotoxic oligomer-forming segment residues 28-38 of the ALS-linked protein, SOD1. The crystal structures reveal three different architectures: corkscrew oligomeric structure, nontwisting curved sheet structure and a steric zipper proto-filament structure. Our work highlights the polymorphism of the segment 28-38 of SOD1 and identifies the molecular features of amyloidogenic entities.

PubMed: 29453800
DOI: 10.1002/pro.3391

実験手法

X-RAY DIFFRACTION (2.77 Å)