5WOB

Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin

Replaces:  4Q5Z

Summary for 5WOB

• Entry DOI: 10.2210/pdb5wob/pdb
• Descriptor: Insulin-degrading enzyme, Insulin, IDE-bound Fab heavy chain, ... (5 entities in total)
• Functional Keywords: hydrolase, complex
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 32
• Total formula weight: 1368634.80

Authors

McCord, L.A.,Liang, W.G.,Farcasanu, M.,Wang, A.G.,Koide, S.,Tang, W.J. (deposition date: 2017-08-01, release date: 2018-04-18, Last modification date: 2023-10-04)

• Primary citation: Zhang, Z.,Liang, W.G.,Bailey, L.J.,Tan, Y.Z.,Wei, H.,Wang, A.,Farcasanu, M.,Woods, V.A.,McCord, L.A.,Lee, D.,Shang, W.,Deprez-Poulain, R.,Deprez, B.,Liu, D.R.,Koide, A.,Koide, S.,Kossiakoff, A.A.,Li, S.,Carragher, B.,Potter, C.S.,Tang, W.J.; Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.; Elife, 7:-, 2018; PubMed: 29596046; DOI: 10.7554/eLife.33572

Experimental method

X-RAY DIFFRACTION (3.95 Å)