5WNH

X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR

5WNH の概要

• エントリーDOI: 10.2210/pdb5wnh/pdb
• 関連するPDBエントリー: 5WNE 5WNF 5WNG
• 分子名称: Rho-associated protein kinase 1, (2R)-N-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamide (3 entities in total)
• 機能のキーワード: rho kinase, kinase inhibitor, phosphorylation, transferase-inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 193995.50

構造登録者

Li, X. (登録日: 2017-07-31, 公開日: 2018-08-01, 最終更新日: 2024-03-13)

• 主引用文献: Li, X.,Marshall, D.,Sibley, R.,Bosanac, T.,Ginn, J.,Kugler, S.,Gautschi, E.,Molinaro, T.,Soleymanzadeh, L.,Shih, C.K.,Young, E.R.R.; Novel mechanism of Rho kinase selectivity: beyond the ATP pocket; To Be Published,

実験手法

X-RAY DIFFRACTION (3.1 Å)