5WMM

Crystal structure of an adenylation domain interrupted by a methylation domain (AMA4) from nonribosomal peptide synthetase TioS

5WMM の概要

• エントリーDOI: 10.2210/pdb5wmm/pdb
• 分子名称: NRPS, MbtH homologue, (2S)-2-amino-3-methylbutanoyl (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl hydrogen (S)-phosphate, ... (7 entities in total)
• 機能のキーワード: nonribosomal peptide, thiocoraline, depsipeptide, thiolation, nucleotidyl transferase, n-methylation, biosynthetic protein
• 由来する生物種: Micromonospora sp. ML1; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112951.57

構造登録者

Pang, A.H.,Mori, S.,Garneau-Tsodikova, S.,Tsodikov, O.V. (登録日: 2017-07-30, 公開日: 2018-03-14, 最終更新日: 2023-10-04)

• 主引用文献: Mori, S.,Pang, A.H.,Lundy, T.A.,Garzan, A.,Tsodikov, O.V.,Garneau-Tsodikova, S.; Structural basis for backbone N-methylation by an interrupted adenylation domain.; Nat. Chem. Biol., 14:428-430, 2018; PubMed: 29556104; DOI: 10.1038/s41589-018-0014-7

実験手法

X-RAY DIFFRACTION (2.9 Å)