5WKD

Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306

Summary for 5WKD

Entry DOI	10.2210/pdb5wkd/pdb
Descriptor	TAR DNA-binding protein 43 (2 entities in total)
Functional Keywords	tdp-43, amyloid, low complexity domain, protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	689.63
Authors	Guenther, E.L.,Trinh, H.,Sawaya, M.R.,Cascio, D.,Eisenberg, D.S. (deposition date: 2017-07-25, release date: 2018-04-18, Last modification date: 2024-04-03)
Primary citation	Guenther, E.L.,Cao, Q.,Trinh, H.,Lu, J.,Sawaya, M.R.,Cascio, D.,Boyer, D.R.,Rodriguez, J.A.,Hughes, M.P.,Eisenberg, D.S. Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25:463-471, 2018 Cited by PubMed: 29786080 DOI: 10.1038/s41594-018-0064-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation