5WJ6

Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004)

5WJ6 の概要

• エントリーDOI: 10.2210/pdb5wj6/pdb
• 関連するPDBエントリー: 5FI6
• 分子名称: Glutaminase kidney isoform, mitochondrial, 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, ... (4 entities in total)
• 機能のキーワード: glutaminase c, inhibitor, complex, glutamine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 238773.42

構造登録者

Huang, Q.,Cerione, R.A. (登録日: 2017-07-21, 公開日: 2018-01-10, 最終更新日: 2023-10-04)

• 主引用文献: Huang, Q.,Stalnecker, C.,Zhang, C.,McDermott, L.A.,Iyer, P.,O'Neill, J.,Reimer, S.,Cerione, R.A.,Katt, W.P.; Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.; J. Biol. Chem., 293:3535-3545, 2018; PubMed: 29317493; DOI: 10.1074/jbc.M117.810101

実験手法

X-RAY DIFFRACTION (2.445 Å)