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5WIM

JAK2 Pseudokinase in complex with AT9283

Summary for 5WIM
Entry DOI10.2210/pdb5wim/pdb
DescriptorTyrosine-protein kinase JAK2, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea (3 entities in total)
Functional Keywordsjak2, pseudokinase, at9283, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight32062.80
Authors
Li, Q.,Eck, M.J.,Li, K.,Park, E. (deposition date: 2017-07-19, release date: 2018-08-01, Last modification date: 2024-03-13)
Primary citationMcNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J.
Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14:587-593, 2019
Cited by
PubMed: 30763067
DOI: 10.1021/acschembio.8b00722
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

217705

数据于2024-03-27公开中

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