5WIM
JAK2 Pseudokinase in complex with AT9283
Summary for 5WIM
Entry DOI | 10.2210/pdb5wim/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea (3 entities in total) |
Functional Keywords | jak2, pseudokinase, at9283, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32062.80 |
Authors | |
Primary citation | McNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J. Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain. ACS Chem. Biol., 14:587-593, 2019 Cited by PubMed: 30763067DOI: 10.1021/acschembio.8b00722 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
Download full validation report