5WHJ
Crystal structure of Fab fragment of anti-FcRn antibody DX-2507
Summary for 5WHJ
| Entry DOI | 10.2210/pdb5whj/pdb |
| Descriptor | DX-2507 Fab heavy chain, DX-2507 Fab light chain (3 entities in total) |
| Functional Keywords | fabricator, fcrn, b2m, beta-2-microglobulin, immune system |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 45641.73 |
| Authors | Edwards, T.E.,Fairman, J.W.,Nixon, A.E.,Kenniston, J.A. (deposition date: 2017-07-17, release date: 2017-09-06, Last modification date: 2023-10-04) |
| Primary citation | Kenniston, J.A.,Taylor, B.M.,Conley, G.P.,Cosic, J.,Kopacz, K.J.,Lindberg, A.P.,Comeau, S.R.,Atkins, K.,Bullen, J.,TenHoor, C.,Adelman, B.A.,Sexton, D.J.,Edwards, T.E.,Nixon, A.E. Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody. J. Biol. Chem., 292:17449-17460, 2017 Cited by PubMed: 28878017DOI: 10.1074/jbc.M117.807396 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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