5WHC

USP7 in complex with Cpd2 (4-(3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl)phenol)

Summary for 5WHC

• Entry DOI: 10.2210/pdb5whc/pdb
• Related: 5WH7
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, 4-[3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]phenol, GLYCEROL, ... (4 entities in total)
• Functional Keywords: hausp, sbdd, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q93009
• Total number of polymer chains: 2
• Total formula weight: 80793.27

Authors

Murray, J.M.,Rouge, L. (deposition date: 2017-07-16, release date: 2017-12-13, Last modification date: 2023-10-04)

• Primary citation: Di Lello, P.,Pastor, R.,Murray, J.M.,Blake, R.A.,Cohen, F.,Crawford, T.D.,Drobnick, J.,Drummond, J.,Kategaya, L.,Kleinheinz, T.,Maurer, T.,Rouge, L.,Zhao, X.,Wertz, I.,Ndubaku, C.,Tsui, V.; Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques.; J. Med. Chem., 60:10056-10070, 2017; PubMed: 29166018; DOI: 10.1021/acs.jmedchem.7b01293

Experimental method

X-RAY DIFFRACTION (2.548 Å)