5WH5
Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-91
Summary for 5WH5
Entry DOI | 10.2210/pdb5wh5/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-[4-(difluoromethoxy)-3-{[(3R)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one, ZINC ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 76245.83 |
Authors | Wang, H. (deposition date: 2017-07-14, release date: 2018-07-18, Last modification date: 2024-03-13) |
Primary citation | Feng, X.,Wang, H.,Ye, M.,Xu, X.T.,Xu, Y.,Yang, W.,Zhang, H.T.,Song, G.,Ke, H. Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors. Biochemistry, 57:4518-4525, 2018 Cited by PubMed: 29975048DOI: 10.1021/acs.biochem.8b00336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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