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5WH5

Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-91

Summary for 5WH5
Entry DOI10.2210/pdb5wh5/pdb
DescriptorcAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-[4-(difluoromethoxy)-3-{[(3R)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one, ZINC ION, ... (5 entities in total)
Functional Keywordsphosphodiesterase, inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight76245.83
Authors
Wang, H. (deposition date: 2017-07-14, release date: 2018-07-18, Last modification date: 2024-03-13)
Primary citationFeng, X.,Wang, H.,Ye, M.,Xu, X.T.,Xu, Y.,Yang, W.,Zhang, H.T.,Song, G.,Ke, H.
Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors.
Biochemistry, 57:4518-4525, 2018
Cited by
PubMed: 29975048
DOI: 10.1021/acs.biochem.8b00336
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

数据于2024-03-27公开中

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