5WG8

Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density

5WG8 の概要

• エントリーDOI: 10.2210/pdb5wg8/pdb
• 分子名称: Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38501.55

構造登録者

D'Arcy, B.M.,Swingle, M.R.,Honkanen, R.E.,Prakash, A. (登録日: 2017-07-13, 公開日: 2018-07-18, 最終更新日: 2023-10-04)

• 主引用文献: D'Arcy, B.M.,Swingle, M.R.,Papke, C.M.,Abney, K.A.,Bouska, E.S.,Prakash, A.,Honkanen, R.E.; The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.; Mol. Cancer Ther., 18:556-566, 2019; PubMed: 30679389; DOI: 10.1158/1535-7163.MCT-17-1143

実験手法

X-RAY DIFFRACTION (1.65 Å)