5WE8

Crystal structure of WNK1 in complex with N-{(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl}-2-(3-methoxyphenyl)-N-methylquinoline-4-carboxamide (compound 8)

5WE8 の概要

• エントリーDOI: 10.2210/pdb5we8/pdb
• 分子名称: Serine/threonine-protein kinase WNK1, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9H4A3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65882.10

構造登録者

Xie, X.,Kohls, D. (登録日: 2017-07-07, 公開日: 2017-08-16, 最終更新日: 2024-03-13)

• 主引用文献: Yamada, K.,Levell, J.,Yoon, T.,Kohls, D.,Yowe, D.,Rigel, D.F.,Imase, H.,Yuan, J.,Yasoshima, K.,DiPetrillo, K.,Monovich, L.,Xu, L.,Zhu, M.,Kato, M.,Jain, M.,Idamakanti, N.,Taslimi, P.,Kawanami, T.,Argikar, U.A.,Kunjathoor, V.,Xie, X.,Yagi, Y.I.,Iwaki, Y.,Robinson, Z.,Park, H.M.; Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.; J. Med. Chem., 60:7099-7107, 2017; PubMed: 28771350; DOI: 10.1021/acs.jmedchem.7b00708

実験手法

X-RAY DIFFRACTION (2.006 Å)