5WDJ

CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-6 AKA 7-(BENZYLOXY)-1H-[1,2, 3]TRIAZOLO[4,5-D]PYRIMIDIN-5-AMINE

Summary for 5WDJ

• Entry DOI: 10.2210/pdb5wdj/pdb
• Descriptor: Myeloperoxidase, alpha-L-fucopyranose, alpha-D-mannopyranose, ... (12 entities in total)
• Functional Keywords: myeloperoxidase, metal binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 135605.64

Authors

Khan, J.A. (deposition date: 2017-07-05, release date: 2018-04-18, Last modification date: 2020-07-29)

• Primary citation: Duclos, F.,Abell, L.M.,Harden, D.G.,Pike, K.,Nowak, K.,Locke, G.A.,Duke, G.J.,Liu, X.,Fernando, G.,Shaw, S.A.,Vokits, B.P.,Wurtz, N.R.,Viet, A.,Valente, M.N.,Stachura, S.,Sleph, P.,Khan, J.A.,Gao, J.,Dongre, A.R.,Zhao, L.,Wexler, R.R.,Gordon, D.A.,Kick, E.K.; Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.; Medchemcomm, 8:2093-2099, 2017; PubMed: 30108726; DOI: 10.1039/c7md00268h

Experimental method

X-RAY DIFFRACTION (2.4 Å)