5WCJ

Crystal Structure of Human Methyltransferase-like protein 13 in complex with SAH

Summary for 5WCJ

• Entry DOI: 10.2210/pdb5wcj/pdb
• Descriptor: Methyltransferase-like protein 13, UNKNOWN ATOM OR ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: methyltransferase, rossman fold, sah-binding, sgc, structural genomics, structural genomics consortium, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 27924.41

Authors

Halabelian, L.,Loppnau, P.,Seitova, A.,Hutchinson, A.,Hunt, B.,Dong, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2017-06-30, release date: 2017-07-19, Last modification date: 2023-10-04)

• Primary citation: Jakobsson, M.E.,Malecki, J.M.,Halabelian, L.,Nilges, B.S.,Pinto, R.,Kudithipudi, S.,Munk, S.,Davydova, E.,Zuhairi, F.R.,Arrowsmith, C.H.,Jeltsch, A.,Leidel, S.A.,Olsen, J.V.,Falnes, P.O.; The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.; Nat Commun, 9:3411-3411, 2018; PubMed: 30143613; DOI: 10.1038/s41467-018-05646-y

Experimental method

X-RAY DIFFRACTION (1.7 Å)