5WBH

Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1

Summary for 5WBH

Entry DOI	10.2210/pdb5wbh/pdb
Descriptor	Serine/threonine-protein kinase mTOR, Ribosomal protein S6 kinase beta-1 (3 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (Human) More
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P42345 Cell junction, synapse, synaptosome . Isoform Alpha I: Nucleus. Isoform Alpha II: Cytoplasm: P23443
Total number of polymer chains	6
Total formula weight	63516.29
Authors	Pavletich, N.P.,Yang, H. (deposition date: 2017-06-29, release date: 2017-12-20, Last modification date: 2023-10-04)
Primary citation	Yang, H.,Jiang, X.,Li, B.,Yang, H.J.,Miller, M.,Yang, A.,Dhar, A.,Pavletich, N.P. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552:368-373, 2017 Cited by PubMed: 29236692 DOI: 10.1038/nature25023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation