5WB7
Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin
5WB7 の概要
エントリーDOI | 10.2210/pdb5wb7/pdb |
分子名称 | Epidermal growth factor receptor, Proepiregulin, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
機能のキーワード | receptor tyrosine kinase, growth factor, signaling, membrane protein, signaling protein |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 260397.57 |
構造登録者 | Freed, D.M.,Bessman, N.J.,Ferguson, K.M.,Lemmon, M.A. (登録日: 2017-06-28, 公開日: 2017-10-18, 最終更新日: 2023-10-04) |
主引用文献 | Freed, D.M.,Bessman, N.J.,Kiyatkin, A.,Salazar-Cavazos, E.,Byrne, P.O.,Moore, J.O.,Valley, C.C.,Ferguson, K.M.,Leahy, D.J.,Lidke, D.S.,Lemmon, M.A. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell, 171:683-695.e18, 2017 Cited by PubMed: 28988771DOI: 10.1016/j.cell.2017.09.017 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.941 Å) |
構造検証レポート
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