5WA8
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Ala phosphoramidate substrate complex
Summary for 5WA8
Entry DOI | 10.2210/pdb5wa8/pdb |
Related | 3TW2 5IPB 5IPC 5KMA 5KMB |
Descriptor | Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{S})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | histidine triad, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P49773 |
Total number of polymer chains | 2 |
Total formula weight | 28612.07 |
Authors | Maize, K.M.,Finzel, B.C. (deposition date: 2017-06-26, release date: 2017-10-18, Last modification date: 2023-10-04) |
Primary citation | Maize, K.M.,Shah, R.,Strom, A.,Kumarapperuma, S.,Zhou, A.,Wagner, C.R.,Finzel, B.C. A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14:3987-3997, 2017 Cited by PubMed: 28968488DOI: 10.1021/acs.molpharmaceut.7b00664 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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