5W9D

Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S Mutant in Complex with Endoxifen

5W9D の概要

• エントリーDOI: 10.2210/pdb5w9d/pdb
• 分子名称: Estrogen receptor, Endoxifen (3 entities in total)
• 機能のキーワード: breast cancer, selective estrogen receptor modulator, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57457.39

構造登録者

Fanning, S.W.,Greene, G.L. (登録日: 2017-06-23, 公開日: 2017-10-11, 最終更新日: 2023-10-04)

• 主引用文献: Maximov, P.Y.,Abderrahman, B.,Fanning, S.W.,Sengupta, S.,Fan, P.,Curpan, R.F.,Rincon, D.M.Q.,Greenland, J.A.,Rajan, S.S.,Greene, G.L.,Jordan, V.C.; Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.; Mol. Pharmacol., 94:812-822, 2018; PubMed: 29739819; DOI: 10.1124/mol.117.111385

実験手法

X-RAY DIFFRACTION (1.6464 Å)