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5W99

Pyridine synthase, PbtD, from GE2270 biosynthesis bound to TSP

Summary for 5W99
Entry DOI10.2210/pdb5w99/pdb
DescriptorPbtD, 2,2'-(6-(2'-(aminomethyl)-[2,4'-bithiazol]-4-yl)pyridine-2,5-diyl)bis(thiazole-4-carboxylic acid), SULFATE ION, ... (4 entities in total)
Functional Keywordspyridine synthase, diels-alder, thiopeptide, biosynthetic protein
Biological sourcePlanobispora rosea
Total number of polymer chains1
Total formula weight38067.73
Authors
Cogan, D.P.,Nair, S.K. (deposition date: 2017-06-22, release date: 2017-11-22, Last modification date: 2023-10-04)
Primary citationCogan, D.P.,Hudson, G.A.,Zhang, Z.,Pogorelov, T.V.,van der Donk, W.A.,Mitchell, D.A.,Nair, S.K.
Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.
Proc. Natl. Acad. Sci. U.S.A., 114:12928-12933, 2017
Cited by
PubMed: 29158402
DOI: 10.1073/pnas.1716035114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.59 Å)
Structure validation

221051

건을2024-06-12부터공개중

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