5W86
CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 7)
Summary for 5W86
Entry DOI | 10.2210/pdb5w86/pdb |
Related | 5w84 5w85 |
Descriptor | Tyrosine-protein kinase JAK3, 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide (3 entities in total) |
Functional Keywords | serine/threonine protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : P52333 |
Total number of polymer chains | 4 |
Total formula weight | 133267.94 |
Authors | Sack, J.S. (deposition date: 2017-06-21, release date: 2017-10-11, Last modification date: 2017-10-25) |
Primary citation | Bhide, R.S.,Keon, A.,Weigelt, C.,Sack, J.S.,Schmidt, R.J.,Lin, S.,Xiao, H.Y.,Spergel, S.H.,Kempson, J.,Pitts, W.J.,Carman, J.,Poss, M.A. Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. Bioorg. Med. Chem. Lett., 27:4908-4913, 2017 Cited by PubMed: 28947151DOI: 10.1016/j.bmcl.2017.09.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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