5W6I

Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with cyclic peptide CP141046 (P3)

5W6I の概要

• エントリーDOI: 10.2210/pdb5w6i/pdb
• 関連するPDBエントリー: 5w5s 5w5u 5w6r 5w6t 5w6u
• 分子名称: Hemagglutinin, ACE-PH8-ORN-LEU-GLU-TYR-PHE-GLU-TRP-LEU-SER-BAL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: glycoprotein, ectodomain, n-glycosylation, viral protein, viral protein-peptide complex, viral protein/peptide
• 由来する生物種: Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 59976.99

構造登録者

Wilson, I.A.,Kadam, R.U. (登録日: 2017-06-16, 公開日: 2017-10-04, 最終更新日: 2023-11-15)

主引用文献

Kadam, R.U.,Juraszek, J.,Brandenburg, B.,Buyck, C.,Schepens, W.B.G.,Kesteleyn, B.,Stoops, B.,Vreeken, R.J.,Vermond, J.,Goutier, W.,Tang, C.,Vogels, R.,Friesen, R.H.E.,Goudsmit, J.,van Dongen, M.J.P.,Wilson, I.A.
Potent peptidic fusion inhibitors of influenza virus.
Science, 358:496-502, 2017

PubMed Abstract: Influenza therapeutics with new targets and mechanisms of action are urgently needed to combat potential pandemics, emerging viruses, and constantly mutating strains in circulation. We report here on the design and structural characterization of potent peptidic inhibitors of influenza hemagglutinin. The peptide design was based on complementarity-determining region loops of human broadly neutralizing antibodies against the hemagglutinin (FI6v3 and CR9114). The optimized peptides exhibit nanomolar affinity and neutralization against influenza A group 1 viruses, including the 2009 H1N1 pandemic and avian H5N1 strains. The peptide inhibitors bind to the highly conserved stem epitope and block the low pH-induced conformational rearrangements associated with membrane fusion. These peptidic compounds and their advantageous biological properties should accelerate the development of new small molecule- and peptide-based therapeutics against influenza virus.

PubMed: 28971971
DOI: 10.1126/science.aan0516

実験手法

X-RAY DIFFRACTION (3.104 Å)