5W5V
TBK1 co-crystal structure with amlexanox
Summary for 5W5V
Entry DOI | 10.2210/pdb5w5v/pdb |
Descriptor | Serine/threonine-protein kinase TBK1, 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid (2 entities in total) |
Functional Keywords | tbk1, kinase, amlexanox, obesity, diabetes, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 76324.22 |
Authors | Beyett, T.S.,Tesmer, J.J.G. (deposition date: 2017-06-15, release date: 2018-06-27, Last modification date: 2023-10-04) |
Primary citation | Beyett, T.S.,Gan, X.,Reilly, S.M.,Chang, L.,Gomez, A.V.,Saltiel, A.R.,Showalter, H.D.,Tesmer, J.J.G. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Mol. Pharmacol., 94:1210-1219, 2018 Cited by PubMed: 30082428DOI: 10.1124/mol.118.112185 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.645 Å) |
Structure validation
Download full validation report