5W5Q

MAP4K4 in complex with inhibitor compound 12 (N3-methyl-10-(3-methyl-3-(5-methyloxazol-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2,3-dicarboxamide)

5W5Q の概要

• エントリーDOI: 10.2210/pdb5w5q/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase kinase 4, (5s,7s)-N~3~-methyl-10-[3-methyl-3-(5-methyl-1,3-oxazol-2-yl)but-1-yn-1-yl]-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide (3 entities in total)
• 機能のキーワード: kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76183.65

構造登録者

Harris, S.F.,Wu, P. (登録日: 2017-06-15, 公開日: 2018-06-20, 最終更新日: 2024-03-13)

• 主引用文献: Feng, J.A.,Lee, P.,Alaoui, M.H.,Barrett, K.,Castanedo, G.,Godemann, R.,McEwan, P.,Wang, X.,Wu, P.,Zhang, Y.,Harris, S.F.,Staben, S.T.; Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).; Acs Med.Chem.Lett., 10:1260-1265, 2019; PubMed: 31531194; DOI: 10.1021/acsmedchemlett.8b00658

実験手法

X-RAY DIFFRACTION (2.33 Å)