5W5O

Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases.

Summary for 5W5O

• Entry DOI: 10.2210/pdb5w5o/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 2, 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine (3 entities in total)
• Functional Keywords: inhibitor, kinase, tetartohedral winning, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : O43353
• Total number of polymer chains: 16
• Total formula weight: 578095.34

Authors

Kreusch, A.,Spraggon, G. (deposition date: 2017-06-15, release date: 2017-10-25, Last modification date: 2024-04-03)

• Primary citation: He, X.,Da Ros, S.,Nelson, J.,Zhu, X.,Jiang, T.,Okram, B.,Jiang, S.,Michellys, P.Y.,Iskandar, M.,Espinola, S.,Jia, Y.,Bursulaya, B.,Kreusch, A.,Gao, M.Y.,Spraggon, G.,Baaten, J.,Clemmer, L.,Meeusen, S.,Huang, D.,Hill, R.,Nguyen-Tran, V.,Fathman, J.,Liu, B.,Tuntland, T.,Gordon, P.,Hollenbeck, T.,Ng, K.,Shi, J.,Bordone, L.,Liu, H.; Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.; ACS Med Chem Lett, 8:1048-1053, 2017; PubMed: 29057049; DOI: 10.1021/acsmedchemlett.7b00258

Experimental method

X-RAY DIFFRACTION (2.89 Å)