5W5O

Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases.

5W5O の概要

• エントリーDOI: 10.2210/pdb5w5o/pdb
• 分子名称: Receptor-interacting serine/threonine-protein kinase 2, 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine (3 entities in total)
• 機能のキーワード: inhibitor, kinase, tetartohedral winning, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : O43353
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 578095.34

構造登録者

Kreusch, A.,Spraggon, G. (登録日: 2017-06-15, 公開日: 2017-10-25, 最終更新日: 2024-04-03)

• 主引用文献: He, X.,Da Ros, S.,Nelson, J.,Zhu, X.,Jiang, T.,Okram, B.,Jiang, S.,Michellys, P.Y.,Iskandar, M.,Espinola, S.,Jia, Y.,Bursulaya, B.,Kreusch, A.,Gao, M.Y.,Spraggon, G.,Baaten, J.,Clemmer, L.,Meeusen, S.,Huang, D.,Hill, R.,Nguyen-Tran, V.,Fathman, J.,Liu, B.,Tuntland, T.,Gordon, P.,Hollenbeck, T.,Ng, K.,Shi, J.,Bordone, L.,Liu, H.; Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.; ACS Med Chem Lett, 8:1048-1053, 2017; PubMed: 29057049; DOI: 10.1021/acsmedchemlett.7b00258

実験手法

X-RAY DIFFRACTION (2.89 Å)