5W5L

Crystal structure of human IgG1-Sigma Fc fragment

5W5L の概要

• エントリーDOI: 10.2210/pdb5w5l/pdb
• 分子名称: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: fc, immunoglobulin fold, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53163.29

構造登録者

Armstrong, A.A.,Gilliland, G.L. (登録日: 2017-06-15, 公開日: 2017-09-13, 最終更新日: 2023-10-04)

• 主引用文献: Tam, S.H.,McCarthy, S.G.,Armstrong, A.A.,Somani, S.,Wu, S.J.,Liu, X.,Gervais, A.,Ernst, R.,Saro, D.,Decker, R.,Luo, J.,Gilliland, G.L.,Chiu, M.L.,Scallon, B.J.; Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.; Antibodies, 6:-, 2017; PubMed: 31548527; DOI: 10.3390/antib6030012

実験手法

X-RAY DIFFRACTION (1.9 Å)