5W5D
Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2B complex
Summary for 5W5D
Entry DOI | 10.2210/pdb5w5d/pdb |
Descriptor | Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ... (8 entities in total) |
Functional Keywords | prefusion primed complex, neuronal exocytosis, synaptotagmin, snare complex, complexin, synchronous neurotransmitter release, exocytosis |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein: P63045 P32851 Cytoplasm, perinuclear region : P60881 P60881 Cytoplasm, cytosol : P63041 Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein : P21707 |
Total number of polymer chains | 6 |
Total formula weight | 56033.07 |
Authors | Zhou, Q.,Brunger, A.T. (deposition date: 2017-06-14, release date: 2017-08-23, Last modification date: 2023-10-04) |
Primary citation | Zhou, Q.,Zhou, P.,Wang, A.L.,Wu, D.,Zhao, M.,Sudhof, T.C.,Brunger, A.T. The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature, 548:420-425, 2017 Cited by PubMed: 28813412DOI: 10.1038/nature23484 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.496 Å) |
Structure validation
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