5W58

Crystal Complex of Cyclooxygenase-2: (S)-ARN-2508 (a dual COX and FAAH inhibitor)

5W58 の概要

• エントリーDOI: 10.2210/pdb5w58/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900017
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: cyclooxygenase, protein-inhibitor complex, prostaglandin, faah-cox dual inhibition, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 69991.39

構造登録者

Xu, S.,Goodman, M.C.,Banerjee, S.,Piomelli, D.,Marnett, L.J. (登録日: 2017-06-14, 公開日: 2018-01-31, 最終更新日: 2023-10-04)

• 主引用文献: Goodman, M.C.,Xu, S.,Rouzer, C.A.,Banerjee, S.,Ghebreselasie, K.,Migliore, M.,Piomelli, D.,Marnett, L.J.; Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.; J. Biol. Chem., 293:3028-3038, 2018; PubMed: 29326169; DOI: 10.1074/jbc.M117.802058

実験手法

X-RAY DIFFRACTION (2.267 Å)