5W55

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048

5W55 の概要

• エントリーDOI: 10.2210/pdb5w55/pdb
• 分子名称: Bromodomain-containing protein 4, 11-ethyl-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, cell cycle
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15716.07

構造登録者

Xu, X.,Blacklow, S.C. (登録日: 2017-06-14, 公開日: 2018-06-20, 最終更新日: 2023-10-04)

• 主引用文献: Xu, X.,Blacklow, S.C.; Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048; To Be Published,

実験手法

X-RAY DIFFRACTION (1.354 Å)