5W3I

Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6e (SRI-29685)

5W3I の概要

• エントリーDOI: 10.2210/pdb5w3i/pdb
• 分子名称: Polymerase acidic protein, MANGANESE (II) ION, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: nuclease, transcription, cap-snatching, virus, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24272.31

構造登録者

Kumar, G.,White, S.W. (登録日: 2017-06-07, 公開日: 2017-12-27, 最終更新日: 2024-03-13)

• 主引用文献: Beylkin, D.,Kumar, G.,Zhou, W.,Park, J.,Jeevan, T.,Lagisetti, C.,Harfoot, R.,Webby, R.J.,White, S.W.,Webb, T.R.; Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.; Sci Rep, 7:17139-17139, 2017; PubMed: 29215062; DOI: 10.1038/s41598-017-17419-6

実験手法

X-RAY DIFFRACTION (1.95 Å)