5W2U

INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 7-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID

5W2U の概要

• エントリーDOI: 10.2210/pdb5w2u/pdb
• 関連するPDBエントリー: 5W26 5W2W 5W2Y
• 分子名称: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: influenza virus neuraminidase, n9, complex, 7-deoxy 2, 3-difluorosialic acid, second binding site, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus (strain A/Tern/Australia/G70C/1975 H11N9)
• 細胞内の位置: Virion membrane : P03472
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46709.47

構造登録者

Streltsov, V.A.,Mckimm-Breschkin, J.,Barrett, S.,Pilling, P.,Hader, S.,Watt, A.G. (登録日: 2017-06-06, 公開日: 2018-02-21, 最終更新日: 2023-10-04)

• 主引用文献: McKimm-Breschkin, J.L.,Barrett, S.,Pilling, P.A.,Hader, S.,Watts, A.G.,Streltsov, V.A.; Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.; J. Med. Chem., 61:1921-1933, 2018; PubMed: 29397718; DOI: 10.1021/acs.jmedchem.7b01467

実験手法

X-RAY DIFFRACTION (2 Å)