5W2U
INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 7-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID
5W2U の概要
エントリーDOI | 10.2210/pdb5w2u/pdb |
関連するPDBエントリー | 5W26 5W2W 5W2Y |
分子名称 | Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
機能のキーワード | influenza virus neuraminidase, n9, complex, 7-deoxy 2, 3-difluorosialic acid, second binding site, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Influenza A virus (strain A/Tern/Australia/G70C/1975 H11N9) |
細胞内の位置 | Virion membrane : P03472 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 46709.47 |
構造登録者 | Streltsov, V.A.,Mckimm-Breschkin, J.,Barrett, S.,Pilling, P.,Hader, S.,Watt, A.G. (登録日: 2017-06-06, 公開日: 2018-02-21, 最終更新日: 2023-10-04) |
主引用文献 | McKimm-Breschkin, J.L.,Barrett, S.,Pilling, P.A.,Hader, S.,Watts, A.G.,Streltsov, V.A. Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives. J. Med. Chem., 61:1921-1933, 2018 Cited by PubMed: 29397718DOI: 10.1021/acs.jmedchem.7b01467 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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