5W19

Tryptophan indole-lyase complex with oxindolyl-L-alanine

Summary for 5W19

• Entry DOI: 10.2210/pdb5w19/pdb
• Descriptor: Tryptophanase, POTASSIUM ION, 1-carboxy-1-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]azaniumyl}-2-[(3R)-2-oxo-2,3-dihydro-1H-indol-3-yl]ethan-1-ide, ... (4 entities in total)
• Functional Keywords: pyridoxal-5'-phosphate, aminotransferase fold, tryptophan metabolism, inhibition, lyase
• Biological source: Proteus vulgaris
• Total number of polymer chains: 4
• Total formula weight: 212189.73

Authors

Phillips, R.S.,Wood, Z.A. (deposition date: 2017-06-02, release date: 2018-06-06, Last modification date: 2023-10-04)

• Primary citation: Phillips, R.S.,Buisman, A.A.,Choi, S.,Hussaini, A.,Wood, Z.A.; The crystal structure of Proteus vulgaris tryptophan indole-lyase complexed with oxindolyl-L-alanine: implications for the reaction mechanism.; Acta Crystallogr D Struct Biol, 74:748-759, 2018; PubMed: 30082510; DOI: 10.1107/S2059798318003352

Experimental method

X-RAY DIFFRACTION (2.1 Å)