5W18
Staphylococcus aureus ClpP in complex with (S)-N-((2R,6S,8aS,14aS,20S,23aS)-2,6-dimethyl-5,8,14,19,23-pentaoxooctadecahydro-1H,5H,14H,19H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-20-yl)-3-phenyl-2-(3-phenylureido)propanamide
Summary for 5W18
Entry DOI | 10.2210/pdb5w18/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, 9V7-PHE-SER-PRO-YCP-ALA-MP8 (3 entities in total) |
Functional Keywords | clpp, hydrolase-antibiotic complex, udep, hydrolase/antibiotic |
Biological source | Staphylococcus aureus (strain NCTC 8325) More |
Total number of polymer chains | 28 |
Total formula weight | 327173.70 |
Authors | Lee, R.E.,Griffith, E.C. (deposition date: 2017-06-02, release date: 2017-08-09, Last modification date: 2023-11-15) |
Primary citation | Griffith, E.C.,Zhao, Y.,Singh, A.P.,Conlon, B.P.,Tangallapally, R.,Shadrick, W.R.,Liu, J.,Wallace, M.J.,Yang, L.,Elmore, J.M.,Li, Y.,Zheng, Z.,Miller, D.J.,Cheramie, M.N.,Lee, R.B.,LaFleur, M.D.,Lewis, K.,Lee, R.E. Ureadepsipeptides as ClpP Activators. Acs Infect Dis., 2019 Cited by PubMed: 31588734DOI: 10.1021/acsinfecdis.9b00245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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