5W0D

Inferred precursor (UCA) of the human antibody lineage K03.12 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006

5W0D の概要

• エントリーDOI: 10.2210/pdb5w0d/pdb
• 関連するPDBエントリー: 5W08
• 分子名称: Hemagglutinin HA1, Lineage K03.12 UCA antibody heavy chain, Lineage K03.12 UCA antibody light chain, ... (8 entities in total)
• 機能のキーワード: influenza neutralizing antibody germline precursor, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Influenza A virus (A/Solomon Islands/3/2006(H1N1)); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 76032.46

構造登録者

McCarthy, K.R.,Harrison, S.C. (登録日: 2017-05-30, 公開日: 2018-02-14, 最終更新日: 2024-10-16)

主引用文献

McCarthy, K.R.,Watanabe, A.,Kuraoka, M.,Do, K.T.,McGee, C.E.,Sempowski, G.D.,Kepler, T.B.,Schmidt, A.G.,Kelsoe, G.,Harrison, S.C.
Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.
Immunity, 48:174-184.e9, 2018

PubMed Abstract: Human B cell antigen-receptor (BCR) repertoires reflect repeated exposures to evolving influenza viruses; new exposures update the previously generated B cell memory (Bmem) population. Despite structural similarity of hemagglutinins (HAs) from the two groups of influenza A viruses, cross-reacting antibodies (Abs) are uncommon. We analyzed Bmem compartments in three unrelated, adult donors and found frequent cross-group BCRs, both HA-head directed and non-head directed. Members of a clonal lineage from one donor had a BCR structure similar to that of a previously described Ab, encoded by different gene segments. Comparison showed that both Abs contacted the HA receptor-binding site through long heavy-chain third complementarity determining regions. Affinities of the clonal-lineage BCRs for historical influenza-virus HAs from both group 1 and group 2 viruses suggested that serial responses to seasonal influenza exposures had elicited the lineage and driven affinity maturation. We propose that appropriate immunization regimens might elicit a comparably broad response.

PubMed: 29343437
DOI: 10.1016/j.immuni.2017.12.009

実験手法

X-RAY DIFFRACTION (1.899 Å)