5W0C

Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex

5W0C の概要

• エントリーDOI: 10.2210/pdb5w0c/pdb
• 分子名称: Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, ethyl {2-[([1,3]thiazolo[4,5-c]pyridine-2-carbonyl)amino]thiophene-3-carbonyl}carbamate, ... (5 entities in total)
• 機能のキーワード: inhibitor complex, p450 monooxygenase, cytochrome p450 2c9, cyp2c9, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55407.88

構造登録者

Johnson, E.F.,Hsu, M.-H. (登録日: 2017-05-30, 公開日: 2017-09-13, 最終更新日: 2023-10-04)

• 主引用文献: Liu, R.,Lyu, X.,Batt, S.M.,Hsu, M.H.,Harbut, M.B.,Vilcheze, C.,Cheng, B.,Ajayi, K.,Yang, B.,Yang, Y.,Guo, H.,Lin, C.,Gan, F.,Wang, C.,Franzblau, S.G.,Jacobs, W.R.,Besra, G.S.,Johnson, E.F.,Petrassi, M.,Chatterjee, A.K.,Futterer, K.,Wang, F.; Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.; Angew. Chem. Int. Ed. Engl., 56:13011-13015, 2017; PubMed: 28815830; DOI: 10.1002/anie.201707324

実験手法

X-RAY DIFFRACTION (2.001 Å)