5VYY

Structure of human Hsp90-alpha bound to resorcinylic inhibitor BnIm

5VYY の概要

• エントリーDOI: 10.2210/pdb5vyy/pdb
• 分子名称: Heat shock protein HSP 90-alpha, methyl 2-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, FORMIC ACID, ... (7 entities in total)
• 機能のキーワード: chaperone, chaperone-inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29361.39

構造登録者

Que, N.S.,Gewirth, D.T. (登録日: 2017-05-26, 公開日: 2018-04-18, 最終更新日: 2024-03-13)

• 主引用文献: Que, N.L.S.,Crowley, V.M.,Duerfeldt, A.S.,Zhao, J.,Kent, C.N.,Blagg, B.S.J.,Gewirth, D.T.; Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.; J. Med. Chem., 61:2793-2805, 2018; PubMed: 29528635; DOI: 10.1021/acs.jmedchem.7b01608

実験手法

X-RAY DIFFRACTION (1.792 Å)