5VWY
Bak core latch dimer in complex with Bim-h3Pc-RT
Summary for 5VWY
Entry DOI | 10.2210/pdb5vwy/pdb |
Descriptor | Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | apoptosis, bcl-2 family, inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 22373.93 |
Authors | Brouwer, J.M.,Colman, P.M.,Czabotar, P.E. (deposition date: 2017-05-23, release date: 2017-11-15, Last modification date: 2024-10-16) |
Primary citation | Brouwer, J.M.,Lan, P.,Cowan, A.D.,Bernardini, J.P.,Birkinshaw, R.W.,van Delft, M.F.,Sleebs, B.E.,Robin, A.Y.,Wardak, A.,Tan, I.K.,Reljic, B.,Lee, E.F.,Fairlie, W.D.,Call, M.J.,Smith, B.J.,Dewson, G.,Lessene, G.,Colman, P.M.,Czabotar, P.E. Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68:659-672.e9, 2017 Cited by PubMed: 29149594DOI: 10.1016/j.molcel.2017.11.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.555 Å) |
Structure validation
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