5VUT
Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)benzonitrile
5VUT の概要
エントリーDOI | 10.2210/pdb5vut/pdb |
分子名称 | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
機能のキーワード | nitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Rattus norvegicus (Rat) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 100156.82 |
構造登録者 | |
主引用文献 | Pensa, A.V.,Cinelli, M.A.,Li, H.,Chreifi, G.,Mukherjee, P.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. J. Med. Chem., 60:7146-7165, 2017 Cited by PubMed: 28776992DOI: 10.1021/acs.jmedchem.7b00835 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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