5VRJ

2009 H1N1 PA Endonuclease in complex with RO-7 and Magnesium

Summary for 5VRJ

• Entry DOI: 10.2210/pdb5vrj/pdb
• Related: 5VP8 5VPT 5VPX 5VQN
• Descriptor: Polymerase acidic protein, SULFATE ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: nuclease influenza inhibitor resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus; More
• Total number of polymer chains: 1
• Total formula weight: 23780.51

Authors

Kumar, G.,White, S.W. (deposition date: 2017-05-10, release date: 2018-04-11, Last modification date: 2024-03-13)

• Primary citation: Jones, J.C.,Kumar, G.,Barman, S.,Najera, I.,White, S.W.,Webby, R.J.,Govorkova, E.A.; Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors.; MBio, 9:-, 2018; PubMed: 29691337; DOI: 10.1128/mBio.00430-18

Experimental method

X-RAY DIFFRACTION (2.302 Å)