5VR9
CH1/Ckappa Fab based on Matuzumab
Summary for 5VR9
Entry DOI | 10.2210/pdb5vr9/pdb |
Related | 5VSH 5VSI |
Descriptor | CH1/Ckappa Fab heavy chain, CH1/Ckappa Fab light chain (3 entities in total) |
Functional Keywords | bispecific antibody, computational design, heavy chain/light chain interface, ch1/ckappa interface, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 94853.20 |
Authors | Hendle, J. (deposition date: 2017-05-10, release date: 2017-08-02, Last modification date: 2023-10-04) |
Primary citation | Froning, K.J.,Leaver-Fay, A.,Wu, X.,Phan, S.,Gao, L.,Huang, F.,Pustilnik, A.,Bacica, M.,Houlihan, K.,Chai, Q.,Fitchett, J.R.,Hendle, J.,Kuhlman, B.,Demarest, S.J. Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies. Protein Sci., 26:2021-2038, 2017 Cited by PubMed: 28726352DOI: 10.1002/pro.3240 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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