5VQU
Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor
Summary for 5VQU
Entry DOI | 10.2210/pdb5vqu/pdb |
Related | 5TER 5VQQ 5VQR 5VQS 5VQT 5VQV 5VQW 5VQX 5VQY 5VQZ |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide, ... (5 entities in total) |
Functional Keywords | polymerase, reverse transcriptase, hiv, non-nucleoside inhibitor, transferase-hydrolase-inhibitor complex, transferase/hydrolase/inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 2 |
Total formula weight | 114567.25 |
Authors | Petrova, Z.O.,Chan, A.H.,Anderson, K.S. (deposition date: 2017-05-09, release date: 2017-08-23, Last modification date: 2023-10-04) |
Primary citation | Chan, A.H.,Lee, W.G.,Spasov, K.A.,Cisneros, J.A.,Kudalkar, S.N.,Petrova, Z.O.,Buckingham, A.B.,Anderson, K.S.,Jorgensen, W.L. Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography. Proc. Natl. Acad. Sci. U.S.A., 114:9725-9730, 2017 Cited by PubMed: 28827354DOI: 10.1073/pnas.1711463114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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