5VQB

Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complex with FAD

5VQB の概要

• エントリーDOI: 10.2210/pdb5vqb/pdb
• 関連するPDBエントリー: 6BRD
• 分子名称: Rifampin monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: rifampin, rifamycin, antibiotic resistance, monooxygenase, oxidoreductase, fad, flavin adenine dinucleotide, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious disease
• 由来する生物種: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 160143.30

構造登録者

Cox, G.,Kelso, J.,Stogios, P.J.,Savchenko, A.,Anderson, W.F.,Wright, G.D.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2017-05-08, 公開日: 2017-08-16, 最終更新日: 2023-10-04)

• 主引用文献: Koteva, K.,Cox, G.,Kelso, J.K.,Surette, M.D.,Zubyk, H.L.,Ejim, L.,Stogios, P.,Savchenko, A.,Sorensen, D.,Wright, G.D.; Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.; Cell Chem Biol, 25:403-412.e5, 2018; PubMed: 29398560; DOI: 10.1016/j.chembiol.2018.01.009

実験手法

X-RAY DIFFRACTION (3.391 Å)