5VOF

DesGla-XaS195A Bound to Aptamer 11F7t and Rivaroxaban

5VOF の概要

• エントリーDOI: 10.2210/pdb5vof/pdb
• 分子名称: Coagulation factor X, DNA/RNA (36-MER), 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, ... (8 entities in total)
• 機能のキーワード: serine protease, blood coagulation, aptamer, inhibitor, hydrolase-hydrolase inhibitor-rna complex, hydrolase/hydrolase inhibitor/rna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 43876.33

構造登録者

Krishnaswamy, S.,Kumar, S. (登録日: 2017-05-02, 公開日: 2018-06-13, 最終更新日: 2023-10-04)

• 主引用文献: Gunaratne, R.,Kumar, S.,Frederiksen, J.W.,Stayrook, S.,Lohrmann, J.L.,Perry, K.,Bompiani, K.M.,Chabata, C.V.,Thalji, N.K.,Ho, M.D.,Arepally, G.,Camire, R.M.,Krishnaswamy, S.,Sullenger, B.A.; Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.; Nat. Biotechnol., 36:606-613, 2018; PubMed: 29863725; DOI: 10.1038/nbt.4153

実験手法

X-RAY DIFFRACTION (2.25 Å)