5VO4

Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With 5-(2-fluoro-4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile

5VO4 の概要

• エントリーDOI: 10.2210/pdb5vo4/pdb
• 分子名称: Androgen receptor, 5-(2-fluoro-4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile (3 entities in total)
• 機能のキーワード: receptor, small molecule inhibitor, hormone receptor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P10275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29390.41

構造登録者

Parris, K.,Unwalla, R. (登録日: 2017-05-02, 公開日: 2018-03-14, 最終更新日: 2024-03-13)

• 主引用文献: Unwalla, R.,Mousseau, J.J.,Fadeyi, O.O.,Choi, C.,Parris, K.,Hu, B.,Kenney, T.,Chippari, S.,McNally, C.,Vishwanathan, K.,Kilbourne, E.,Thompson, C.,Nagpal, S.,Wrobel, J.,Yudt, M.,Morris, C.A.,Powell, D.,Gilbert, A.M.,Chekler, E.L.P.; Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.; J. Med. Chem., 60:6451-6457, 2017; PubMed: 28696695; DOI: 10.1021/acs.jmedchem.7b00373

実験手法

X-RAY DIFFRACTION (2.35 Å)