5VO2

DLK in complex with inhibitor 5-(1-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine (compound 7)

5VO2 の概要

• エントリーDOI: 10.2210/pdb5vo2/pdb
• 関連するPDBエントリー: 5VO1
• 分子名称: Mitogen-activated protein kinase kinase kinase 12, 5-{5-[1-(oxetan-3-yl)piperidin-4-yl]-1-(propan-2-yl)-1H-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amine (3 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q12852
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34427.48

構造登録者

HARRIS, S.F.,YIN, J. (登録日: 2017-05-01, 公開日: 2017-10-04, 最終更新日: 2023-10-04)

• 主引用文献: Patel, S.,Meilandt, W.J.,Erickson, R.I.,Chen, J.,Deshmukh, G.,Estrada, A.A.,Fuji, R.N.,Gibbons, P.,Gustafson, A.,Harris, S.F.,Imperio, J.,Liu, W.,Liu, X.,Liu, Y.,Lyssikatos, J.P.,Ma, C.,Yin, J.,Lewcock, J.W.,Siu, M.; Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.; J. Med. Chem., 60:8083-8102, 2017; PubMed: 28929759; DOI: 10.1021/acs.jmedchem.7b00843

実験手法

X-RAY DIFFRACTION (2.96 Å)