5VNS

M.tb Antigen 85C Acyl-Enzyme Intermediate with Tetrahydrolipstatin

5VNS の概要

• エントリーDOI: 10.2210/pdb5vns/pdb
• 分子名称: Diacylglycerol acyltransferase/mycolyltransferase Ag85C, (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
• 機能のキーワード: enzyme-acyl intermediate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34177.07

構造登録者

Goins, C.M.,Ronning, D.R. (登録日: 2017-05-01, 公開日: 2018-01-24, 最終更新日: 2019-12-11)

• 主引用文献: Goins, C.M.,Dajnowicz, S.,Smith, M.D.,Parks, J.M.,Ronning, D.R.; Mycolyltransferase fromMycobacterium tuberculosisin covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis.; J. Biol. Chem., 293:3651-3662, 2018; PubMed: 29352107; DOI: 10.1074/jbc.RA117.001681

実験手法

X-RAY DIFFRACTION (1.45 Å)