5VNP
X-ray crystal structure of Halotag bound to the P1 benzoxadiazole fluorogenic ligand
Summary for 5VNP
Entry DOI | 10.2210/pdb5vnp/pdb |
Descriptor | Haloalkane dehalogenase, N-{2-[2-(hexyloxy)ethoxy]ethyl}-N~2~-methyl-N~2~-{[7-(methylamino)-2,1,3-benzoxadiazol-4-yl]sulfonyl}glycinamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | biosensor, cytotoxicity, fluorescent probe, protein aggregation, proteome stress, hydrolase |
Biological source | Rhodococcus rhodochrous |
Total number of polymer chains | 2 |
Total formula weight | 66867.36 |
Authors | Dunham, N.P.,Boal, A.K. (deposition date: 2017-05-01, release date: 2017-06-14, Last modification date: 2023-10-04) |
Primary citation | Liu, Y.,Fares, M.,Dunham, N.P.,Gao, Z.,Miao, K.,Jiang, X.,Bollinger, S.S.,Boal, A.K.,Zhang, X. AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress. Angew. Chem. Int. Ed. Engl., 56:8672-8676, 2017 Cited by PubMed: 28557281DOI: 10.1002/anie.201702417 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
Download full validation report