5VMX
Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a hemi CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS)
Summary for 5VMX
Entry DOI | 10.2210/pdb5vmx/pdb |
Related | 5VMU 5VMV 5VMW 5VMY 5VMZ |
Descriptor | Transcriptional regulator Kaiso, DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*(5CM)P*GP*(5CM)P*GP*AP*AP*TP*AP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*CP*GP*CP*GP*GP*GP*AP*AP*GP*CP*A)-3'), ... (6 entities in total) |
Functional Keywords | dna methylation, zinc finger, transcriptional regulator, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q86T24 |
Total number of polymer chains | 3 |
Total formula weight | 27510.66 |
Authors | Nikolova, E.N.,Stanfield, R.L.,Martinez-Yamout, M.A.,Dyson, H.J.,Wright, P.E. (deposition date: 2017-04-28, release date: 2018-04-04, Last modification date: 2023-10-04) |
Primary citation | Nikolova, E.N.,Stanfield, R.L.,Dyson, H.J.,Wright, P.E. CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57:2109-2120, 2018 Cited by PubMed: 29546986DOI: 10.1021/acs.biochem.8b00065 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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