5VMG

Influenza hemagglutinin H1 mutant DH1E in complex with 6'SLN

Summary for 5VMG

• Entry DOI: 10.2210/pdb5vmg/pdb
• Related PRD ID: PRD_900046
• Descriptor: Hemagglutinin HA1, Hemagglutinin HA2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: influenza, hemagglutinin, receptor, viral protein
• Biological source: Influenza A virus (A/New_York/1/18(H1N1)); More
• Total number of polymer chains: 6
• Total formula weight: 176330.18

Authors

Ni, F.,Kondrashkina, E.,Wang, Q. (deposition date: 2017-04-27, release date: 2017-11-08, Last modification date: 2024-10-16)

Primary citation

Ni, F.,Kondrashkina, E.,Wang, Q.
Determinant of receptor-preference switch in influenza hemagglutinin.
Virology, 513:98-107, 2017

PubMed Abstract: Influenza pandemic occurs when a new strain from other animal species overcomes the inter-species barriers and supports rapid human-to-human transmission. A critical prerequisite to this process is that hemagglutinin (HA) acquires a few key mutations to switch from avian receptors to human receptors. Previous studies suggest that H1 and H2/H3 HAs use different sets of mutations for the switch. This report shows that HA from the 1918 H1N1 pandemic virus (1918H1 HA) adopts the set of mutations used by H2/H3 HAs in receptor-preference switch when its 130-loop is made similar to those of H2/H3 HAs. Thus, the 130-loop appears to be the key determinant for the different mutations employed by pandemic H1 or H2/H3 HA. The correlation of the mutational routes and the 130-loop as unraveled in this study opens the door for efficient investigation of mutations required by other HA subtypes for inter-human airborne transmission.

PubMed: 29055255
DOI: 10.1016/j.virol.2017.10.010

Experimental method

X-RAY DIFFRACTION (2.45 Å)